Wondering what the best supplements for heart health are? The truth is, supplementation is highly personalized based on your specific situation. 

As a cardiovascular dietitian, I believe supplements should never replace a strong nutrition foundation. In some cases, they may help address specific nutrient gaps or support certain aspects of cardiovascular health. but their use should always be individualized and based on a person’s overall health picture.

This article breaks down the top 5 supplements for heart health, why nutrient adequacy matters, and my food first philosophy.

Disclaimer 

Before we dive into supplements for heart health, I want to make a few important disclaimers: 

• This is general information, not medical advice, and it’s important to be aware that not all of these supplements are a good idea for everyone — especially if you’re on blood thinners or other medications that can interact with certain supplements. 
• I’m a foods-first cardiovascular dietitian, which means I always encourage my clients to get their essential nutrients primarily from their diet. When this is not possible, certain supplements may be a great way to complement their healthy diet and support blood pressure control. 
• Whether a supplement is right for you depends on your personal needs, including what medications you’re on. Discuss this with a dietitian who specializes in heart disease to determine whether it’s appropriate for you.

With that in mind, let’s explore the best supplements for heart health and how they may help in certain situations.

Why Nutrient Adequacy Matters for Heart Health 

Many of the clients I work with as a dietitian think that heart health is mostly about what you avoid. Less sugar, less fried foods, less processed foods. While these things can help, my philosophy focuses on nutrient adequacy. 

Nutrient adequacy means you’re consistently getting the vitamins, minerals, and nutrients your body needs to help keep everything functioning properly. Getting enough nutrients supports processes like healthy blood pressure, balanced cholesterol levels, steady blood sugar, and lower inflammation. 

My approach is food first, focusing on science based nutrition as the foundation. When food alone isn’t enough, targeted heart health supplements can fill specific gaps. Supplements are individualized. Recommendations depend on factors like your age, gender, labs, kidney, liver function, what you eat (and what you don’t), medical history, and medication list. 

If someone is selling supplements to everyone, take that as a red flag. Without evaluating individual factors that influence how a supplement affects you, it’s impossible to know whether it will benefit you.

Omega-3s 

Omega-3 fatty acids are essential fats that your body can’t produce enough of, so you have to get an adequate amount through food like fatty fish, seafood, and algae. The omega-3s EPA and DHA help improve blood vessel dilation and support nitric oxide production, which promotes healthier circulation and may modestly lower blood pressure.

Most people don’t have an optimal omega-3 index above 8%. The omega-3 index is a blood test that measures the percentage of EPA and DHA in your red blood cell membranes, which reflects longer-term omega-3 status.

If you don’t consume omega-3 rich fish about three times per week, it may be helpful to check your omega-3 status to determine whether increasing EPA and DHA intake is needed. Additionally, if relying primarily on plant-based sources of omega-3s like chia seeds or flaxseed, keep in mind that only about 1–10% of ALA (alpha-linolenic acid) is converted into EPA, and even less is converted into DHA.

A registered dietitian should evaluate your diet, lab values, medications, and cardiovascular risk before recommending supplements. Most experts recommend staying at or below 3 grams per day total, with no more than about 2 grams coming from supplements. Higher doses may increase bleeding risk in those taking blood thinners, raise the risk of atrial fibrillation in some individuals, and high-dose DHA can slightly raise LDL cholesterol levels.

Plant Sterols and Stanols 

Plant sterols and stanols are naturally occurring compounds found in small amounts in nuts, seeds, whole grains, legumes, and vegetable oils. Structurally similar to cholesterol, they compete with dietary cholesterol for absorption in the intestines. This reduces the amount of cholesterol that enters the bloodstream, prompting modest but meaningful reductions in LDL cholesterol. 

A large meta-analysis of more than 40 studies found that consuming about 2 grams per day of plant sterols or stanols lowered LDL cholesterol by roughly 10%. Fortified foods or supplements can provide higher amounts than diet alone.

They are generally well tolerated, but shouldn’t be used in individuals with sitosterolemia and are most effective when combined with additional science based nutrition strategies. I often recommend considering a cholesterol balance test before using plant sterol supplements to determine whether they may be appropriate for you.

If you hyperabsorb beta-sitosterol, clinicians generally do not recommend plant sterol supplements because they can increase cholesterol levels.

Soluble Fiber 

Soluble fiber binds bile acids in the gut and carries them out of the body. Because the body uses cholesterol to produce bile acids, the liver pulls LDL cholesterol from the bloodstream to replace what it used, lowering circulating LDL levels over time.

Additionally, fiber supports healthy blood sugar regulation and a healthy gut microbiome, both of which support cardiovascular health. 

You can take a soluble fiber supplement; however, it’s difficult to get your daily needs through a supplement alone. You can get soluble fiber through foods like oats, beans, lentils, fruit, and seeds. When you get your soluble fiber from food, you’re also getting additional key nutrients like potassium and antioxidants to further support your health. 

Magnesium 

Magnesium supports hundreds of processes in the body, including many that directly affect heart and vascular function. It helps regulate blood vessel relaxation, supports steady electrical signaling in cardiac cells, and plays a role in maintaining normal heart rhythm. 

Adequate magnesium levels are associated with a reduction in both systolic and diastolic blood pressure, improved circulation, and a lower risk of certain rhythm disturbances. It’s important to note that adequate means not too much, and not too little, but rather maintaining magnesium homeostasis. Too much can lead to toxicity, which can be harmful to your liver and kidneys. I’ve seen cases where excessive magnesium supplementation has negatively affected bone health.

Magnesium is widely available in leafy greens, legumes, seeds, nuts, and whole grains. Many people meet their needs through food, but deficiency is still common due to low intake, GI conditions, and certain medications. 

If you take blood pressure medication, speak with your healthcare provider before supplementing because it can amplify blood pressure-lowering effects, and your provider should personalize dosing.

CoQ10

Coenzyme Q10, or CoQ10, is a compound that helps cells produce energy, especially in high-demand organs like the heart. It also helps protect blood vessel cells from damage caused by oxidative stress, which can contribute to stiffness and impaired circulation over time.

Ubiquinol is the active, reduced form of CoQ10, which is the preferred form as you age or if you take statins to help avoid side effects. Ensure you speak with a doctor or dietitian specialized in heart disease to make sure it doesn’t interact with your blood pressure or heart medications. 

Research suggests that CoQ10 supplementation may modestly lower both systolic and diastolic blood pressure and may also support heart function in individuals with heart failure. Because CoQ10 levels naturally decline as we age, some adults may benefit from supplementation under the guidance of a healthcare professional.

Using Supplements for Heart Health Safely

While there is promising research on nutrients like omega-3s, magnesium, plant sterols, and CoQ10, healthcare professionals, including myself, cannot give supplement advice without knowing the following:  

• Age
• Gender
• Labs
• Kidney
• Liver function
• What you eat 
• Medical history 
• Medication list 

Each of these factors influences safety, dosing, interactions, and whether a specific supplement is appropriate for your situation. 

Additionally, consider these three factors to ensure you’re using heart health supplements safely: 

• Third party verification: Look for supplements with third party verification. This means an independent organization has tested the supplement to confirm it contains what the label claims, is free from contaminants, and meets quality standards. 
• Dosing: Appropriate dosing is crucial for safety, as taking more than the recommended amount can increase the risk of side effects, interactions, or toxicity.
• Storage conditions: Keep your supplements in a cool, dry place away from heat, light, and moisture. Don’t order your supplements from Amazon, as they may not be stored properly, and the online marketplace is loosely regulated. It’s best to purchase from a trusted pharmacy or order directly from the manufacturer. 

Targeted, science based nutrition works best when it’s tailored to you by working with a registered dietitian. If you’re interested in working with me, you can set up a free discovery call to learn more.

FAQs on Supplements for Heart Health 

Are there supplements for heart health? 

Supplements are intended to supplement the diet and are most appropriate when there’s a specific indication (like a documented deficiency or higher-risk situation). Routine vitamin/mineral supplementation in generally healthy adults has not been shown to prevent cardiovascular disease events.

These include omega-3 fatty acids, magnesium, soluble fiber, plant sterols, and CoQ10. You shouldn’t take these blindly. Use lab testing and a personalized assessment to determine what you need beyond a heart-healthy diet.

Is magnesium supplements good for heart health? 

Magnesium supplements may support heart health by helping regulate blood pressure, vascular tone, and heart rhythm, particularly in individuals with low magnesium levels. Supplementation should be personalized, especially if you take cardiac medications.

What is best supplement for heart health? 

There is no single best supplement for heart health. The best option for you depends on your labs, medical history, diet, medications, and more. You can work with a cardiovascular dietitian to create a personalized science based nutrition plan. 

Is collagen supplement good for heart health? 

There’s currently limited evidence on collagen supplements being beneficial for heart health. It does support pain reduction in osteoarthritis, but it’s not considered a primary supplement for heart health. 

Can supplements actually improve heart health? 

Clinical trials show that routine vitamin and mineral supplementation has not been shown to reduce the risk of major adverse cardiovascular events (MACE) in the general population. However, certain supplements may help improve markers like LDL cholesterol, triglycerides, or blood pressure when used in the right clinical context. 

For example, targeted nutrients such as methylated B vitamins may be considered in individuals with elevated homocysteine levels when a deficiency or impaired methylation pathway is contributing. Meaningful improvements in heart health typically require a comprehensive approach that prioritizes personalization rather than relying on supplements alone.

References

1. Barkas, F., Bathrellou, E., Nomikos, T., Panagiotakos, D., Liberopoulos, E., & Kontogianni, M. D. (2023). Plant Sterols and Plant Stanols in Cholesterol Management and Cardiovascular Prevention. Nutrients, 15(13), 2845. https://doi.org/10.3390/nu15132845

2. Ghavami, A., Ziaei, R., Talebi, S., Barghchi, H., Nattagh-Eshtivani, E., Moradi, S., Rahbarinejad, P., Mohammadi, H., Ghasemi-Tehrani, H., Marx, W., & Askari, G. (2023). Soluble Fiber Supplementation and Serum Lipid Profile: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials. Advances in nutrition (Bethesda, Md.), 14(3), 465–474. https://doi.org/10.1016/j.advnut.2023.01.005

3. National Institutes of Health, Office of Dietary Supplements. (2024). Omega-3 fatty acids: Fact sheet for health professionals. https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/

4. Bercea, C. I., Cottrell, G. S., Tamagnini, F., & McNeish, A. J. (2021). Omega-3 polyunsaturated fatty acids and hypertension: a review of vasodilatory mechanisms of docosahexaenoic acid and eicosapentaenoic acid. British journal of pharmacology, 178(4), 860–877. https://doi.org/10.1111/bph.15336

5. Schutten, J. C., Joosten, M. M., de Borst, M. H., & Bakker, S. J. L. (2018). Magnesium and Blood Pressure: A Physiology-Based Approach. Advances in chronic kidney disease, 25(3), 244–250. https://doi.org/10.1053/j.ackd.2017.12.003

6. Rosenfeldt, F. L., Haas, S. J., Krum, H., Hadj, A., Ng, K., Leong, J. Y., & Watts, G. F. (2007). Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. Journal of human hypertension, 21(4), 297–306. https://doi.org/10.1038/sj.jhh.1002138

7. Katan, M. B., Grundy, S. M., Jones, P., Law, M., Miettinen, T., Paoletti, R., & Stresa Workshop Participants (2003). Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo Clinic proceedings, 78(8), 965–978. https://doi.org/10.4065/78.8.965

8. Lane, K. E., Wilson, M., Hellon, T. G., & Davies, I. G. (2022). Bioavailability and conversion of plant based sources of omega-3 fatty acids – a scoping review to update supplementation options for vegetarians and vegans. Critical reviews in food science and nutrition, 62(18), 4982–4997. https://doi.org/10.1080/10408398.2021.1880364

9. Castiglioni, S., Cazzaniga, A., Albisetti, W., & Maier, J. A. M. (2013). Magnesium and Osteoporosis: Current State of Knowledge and Future Research Directions. Nutrients, 5(8), 3022-3033. https://doi.org/10.3390/nu5083022

10. Kim, J., Choi, J., Kwon, S. Y., McEvoy, J. W., Blaha, M. J., Blumenthal, R. S., Guallar, E., Zhao, D., & Michos, E. D. (2018). Association of Multivitamin and Mineral Supplementation and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis. Circulation. Cardiovascular quality and outcomes, 11(7), e004224. https://doi.org/10.1161/CIRCOUTCOMES.117.004224

11. Wu, X., & Fang, T. (2026). Advances in cardiovascular supplementation: mechanisms, efficacy, and clinical perspectives. Frontiers in molecular biosciences, 12, 1699492. https://doi.org/10.3389/fmolb.2025.1699492

12. Cheng, X., Chen, Z., Fang, Y., Zhang, Q., Chen, B., Xi, W., Pan, Z., & Guo, L. (2025). Effect of vitamin D supplementation for major adverse cardiovascular events: a meta-analysis based on randomised controlled trials. The British journal of nutrition, 134(2), 124–133. https://doi.org/10.1017/S0007114525103954